Protein Modification Reagents
Medchemexpress LLC DSPE PEG thiol | 25322-68-3 | 99.4% | 2000 (average) | 100 MG
DSPE-PEG-SH (MW 2000) is a thiol-terminated pegylated phospholipid used to introduce reactive thiol groups into lipid assemblies. The thiol group readily forms stable thioether linkages with maleimide and other electrophiles, enabling surface functionalization of liposomes and lipid nanoparticles for targeted delivery and conjugation of ligands such as peptides or antibodies.
- Thiol terminus enables covalent conjugation with maleimide groups.
- Incorporates into liposomes and lipid nanoparticles for surface functionalization.
- Amphipathic structure supports bilayer formation in aqueous systems.
- High purity (≈99.4%) suitable for research applications.
- Soluble in water and DMSO with warming and sonication.
Medchemexpress LLC Dspe-peg-sh | 99.4% | 2000 (average) | (C2H4O)nC45H87N2O10PS | 25 MG
DSPE-PEG-SH is a thiolated pegylated phospholipid (average MW 2000) that provides a terminal -SH for covalent surface modification of lipid assemblies. Its amphipathic DSPE-PEG structure enables incorporation into liposomes and lipid nanoparticles for ligand attachment, stabilization, and targeted delivery via formation of stable thioether bonds with maleimide-functionalized molecules.
- Provides a terminal thiol for covalent conjugation.
- Incorporates into lipid bilayers for surface functionalization.
- Enables stable thioether linkage with maleimide reagents.
- Suitable for liposome and lipid nanoparticle formulations.
- Facilitates targeted delivery via ligand attachment.
- Reported high purity supports reproducible formulation.
- Soluble in water and DMSO with warming and sonication.
Medchemexpress LLC DSPE-PEG-DBCO | 99.9% | 2000 (average) | 25 MG
DSPE-PEG-DBCO (MW 2000) is a PEGylated phospholipid conjugate bearing a dibenzocyclooctyne (DBCO) group. It serves as a click-chemistry-capable lipid for incorporation into lipid nanoparticles or micelles and for rapid, copper-free conjugation to azide-containing molecules via strain-promoted alkyne-azide cycloaddition (SPAAC). Typical uses include nanoparticle formulation, surface PEGylation, and bioconjugation.
- PEGylated phospholipid with average molecular weight 2000.
- DBCO functional group enables copper-free SPAAC with azides.
- Suitable for lipid nanoparticle and micelle formulation.
- Facilitates bioconjugation and surface modification.
- High purity (reported 99.9%) for research applications.
Medchemexpress LLC Dspe-peg-biotin | 98.4% | 3400 Da (average) | 100 MG
DSPE-PEG-Biotin (average MW 3400) is a phospholipid-polyethylene glycol conjugate designed for biotinylation and incorporation into lipid assemblies. Its amphiphilic character supports use in liposomes, micelles, and targeted drug delivery research, and it is supplied as a solid for laboratory handling.
- Facilitates biotinylation of molecules.
- Amphiphilic; integrates into lipid membranes and liposomes.
- Average molecular weight 3400 Da.
- Provided as a white solid for convenient handling.
- High purity (≈98.4%) suitable for research applications.
- Powder stable at -20°C; in solvent store at -80°C for longer-term storage.
Medchemexpress LLC Pomalidomide-amido-C5-PEG2-C6-chlorine | 1835705-69-5 | 98.75% | 594.10 | 1 MG
Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivative of Pomalidomide (HY-10984). It is supplied as a solid, white to off-white in color, and is intended for research use only, not for sale to patients.
- Derivative of Pomalidomide
- For research use only
- Solid, white to off-white appearance
- Ships at room temperature in continental US
- Store at 4°C under nitrogen
- Store in solvent at -80°C for 6 months
- Store in solvent at -20°C for 1 month
Worthington Biochemical Corporation PAPAIN SUSPENSION 1GM
Supplied as a 2X crystalline suspension in 50 mM sodium acetate, pH 4.5. To insure full activity, the enzyme should be incubated in a solution containing 1.1 mM EDTA, 0.067 mM mercaptoethanol and 5.5 mM cysteine-HCl for 30 minutes. It is recommended that the enzyme be 0.22 micron filtered after dissolution and prior to use. 9001-73-4
Medchemexpress LLC Biotin-PEG2-acid | 1365655-89-5 | >97.0% | 403.49 g/mol | C17H29N3O6S | 50 MG
Biotin-PEG2-acid is a non-cleavable, two-unit polyethylene glycol (PEG) linker bearing a biotin affinity tag and a terminal carboxylic acid. It is supplied as an off-white to gray solid and is used to introduce hydrophilicity and a biotin handle in conjugation chemistries such as ADC and PROTAC synthesis.
- Non-cleavable two-unit PEG spacer improves solubility and linker flexibility.
- Terminal carboxylic acid enables standard conjugation chemistries.
- Biotin tag allows affinity capture and detection.
- High purity suitable for research applications.
- Available in multiple pack sizes including 50 MG for small-scale use.
BEZWADA BIOMEDICAL LLC PEG Diacrylate, MW 2000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
Medchemexpress LLC Hydroxy-PEG4-(CH2)2-Boc | 518044-32-1 | MFCD11041117 | 99.3% | 322.39 g/mol | C15H30O7 | 100 G
Hydroxy-PEG4-(CH2)2-Boc is a PEG4-based linker with a terminal hydroxyl and a tert-butyl (Boc) protected group, supplied for use in synthetic and medicinal chemistry applications such as antibody-drug conjugate (ADC) and PROTAC assembly. It is a non-cleavable spacer with a molecular weight of 322.39 g/mol and a chemical formula of C15H30O7.
- PEG4 spacer with terminal hydroxyl
- Boc-protected tert-butyl ester functional group
- Non-cleavable linker for ADC and PROTAC assembly
- Approximately 99.3% purity suitable for medicinal chemistry
- Available in laboratory-scale pack sizes, including 100 G
- Recommended storage: -20°C for long-term stability; follow solvent-specific conditions
Medchemexpress LLC Gly-gly-gly-PEG4-DBCO | 2353409-80-8 | 95.1% | 694.77 g/mol | C35H46N6O9 | 5 MG
Gly-gly-gly-PEG4-DBCO is a 4-unit polyethylene glycol (PEG) linker bearing a dibenzocyclooctyne (DBCO) moiety used for copper-free click chemistry (strain-promoted alkyne-azide cycloaddition, SPAAC) in bioconjugation workflows such as antibody-drug conjugate synthesis. It is supplied as a solid in small-mass vials for research use.
- 4-unit PEG linker enabling flexible spacing in conjugates.
- DBCO moiety for SPAAC (copper-free click) with azide-containing partners.
- Suitable for antibody-drug conjugate synthesis and general bioconjugation.
- Solid, light yellow to yellow appearance for convenient handling.
- Reported purity 95.1% supports research-grade applications.
Medchemexpress LLC Cc-885-ch2-peg1-nh-ch3 | 2722698-03-3 | 99.2% | 528.00 | C26H30ClN5O5 | 25 MG
CC-885-CH2-PEG1-NH-CH3 is a small-molecule neoDegrader used as the cytotoxic payload in antibody-based neoDegrader conjugates (AnDCs) to enable targeted protein degradation via the E3 ubiquitin ligase pathway. It is supplied for laboratory research use.
- Used in synthesis of antibody neoDegrader conjugates.
- Enables targeted protein degradation via the E3 ubiquitin ligase pathway.
- Molecular formula C26H30ClN5O5; molecular weight 528.00 g/mol.
- Purity 99.2% and solid, white to off-white appearance.
- Storage: 4°C (sealed); in solvent, -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC endo-BCN-PEG4-PFP ester | 2904607-26-5 | 95.0% | 607.56 | 100 MG
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, featuring a BCN group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a BCN group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs utilize the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
Medchemexpress LLC DSPE-PEG6-Mal | 95.0% | 1163.50 | 25 MG
DSPE-PEG6-Mal is a chemical compound identified by the molecular formula C60H111N2O17P and a molecular weight of 1163.50. It appears as a white to off-white solid.
- Appears as a white to off-white solid
- 1H NMR spectrum consistent with its structure
- Purity of 95.0% confirmed by NMR
- Store at -20°C in sealed container, away from moisture
- If in solvent, store at -80°C for up to 6 months or -20°C for 1 month in sealed container, away from moisture
Medchemexpress LLC Cholesterol-PEG 600 | 69068-97-9 | <1% | 1055.60 g/mol | C68H110O8 | 250 MG
Cholesterol-PEG 600 is a cholesterol-polyethylene glycol conjugate supplied for research use, provided as an off-white to light yellow oil. It is designed to introduce cholesterol moieties into membranes or to increase water solubility of lipid-modified constructs for biochemical and formulation studies.
- Cholesterol-PEG conjugate for membrane anchoring and formulation.
- Soluble in water (~60 mg/mL) with ultrasonic and warming.
- Appearance: off-white to light yellow oil.
- Storage: store pure material at -20°C; in solvent, -80°C for long term; aliquot to avoid freeze-thaw.
- Certificate of analysis shows total cholesterol ~20.4% and free cholesterol <1%.
- Available in multiple pack sizes from milligram to gram quantities.
New England Biolabs, Inc. NEBExpress Salt Active Nuclease, GMP Grade - 1 ml
NEBExpress Salt Active Nuclease, GMP Grade is a recombinant, engineered broad-specificity nuclease, designed to leverage high salt conditions to degrade nucleic acids in protein, adeno-associated virus (AAV), and biopharmaceutical manufacturing workflows for easier and more complete removal of these impurities. NEBExpress Salt Active Nuclease, GMP Grade is manufactured according to New England Biolabs’ GMP-grade* quality standards for stringent quality documentation and manufacturing needs. NEBExpress Salt Active Nuclease, GMP Grade is up to 2X more active than other nucleases at high salt to enable increased productivity and reduce costs. This GMP-grade enzyme is formulated at high concentration and activity to minimize sample dilution. NEBExpress Salt Active Nuclease, GMP Grade degrades all forms of DNA and RNA at a broad range of salt concentrations, with optimal activity at 500 mM NaCl/KCl.